New Inhibitors of Dual-specificity Protein Phosphatase Cdc25C from Plants

doi:10.3724 SP.J.1143.2008.07295

Plant Diversity ›› 2008, Vol. 30 ›› Issue (05): 617-620.DOI: 10.3724 SP.J.1143.2008.07295

• Articles • Previous Articles Next Articles

New Inhibitors of Dual-specificity Protein Phosphatase Cdc25C from Plants

JIA Rui-Rui¹ , ZENG Guang-Zhi¹ , TAN Ning-Hua¹, FAN Jun-Ting¹ ^{, 2} ,
HUANG Huo-Qiang^{1 , 2} , JI Chang-Jiu^{1 , 2} , HAO Xiao-Jiang¹,
ZHAO Qin-Shi¹ , LI Chao-Ming¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany , Chinese Academy
of Sciences, Kunming 650204 , China ; 2 Graduate School of the Chinese Academy of Sciences , Beijing 100049 , China

Received:2007-12-14 Online:2008-10-25 Published:2008-10-25

Abstract

Abstract: Protein phosphatase Cdc25C dephosphorylates the mitotic kinase CDK1 cyclin B, and then triggers the cell cycle progression. Overexpression of Cdc25C is detected in some cancer cells, which made it to be a potential target for anti-cancer drugs. Through Cdc25C assay, compounds 1 - 8 were found to be new natural inhibitors against Cdc25C with IC50 s of 1.66 - 75.07
μmol/L. Moreover , 3 , 4 , 5 and 7 exhibited cytotoxicities on a panel of ten cancer cell lines with IC50 s below 10μg/mL.

Key words: Cdc25C

CLC Number:

Q 946

JIA Rui-Rui , ZENG Guang-Zhi , TAN Ning-Hua, FAN Jun-Ting ^, ,
HUANG Huo-Qiang^, , JI Chang-Jiu^, , HAO Xiao-Jiang,
ZHAO Qin-Shi , LI Chao-Ming. New Inhibitors of Dual-specificity Protein Phosphatase Cdc25C from Plants[J]. Plant Diversity, 2008, 30(05): 617-620.

[1]	LAI GuoFang, DONG XuJun , YANG JianKun, LUO HuaiRong, WANG YiFen. One New Sesquilignan from Illicium spathulatum （Illiciaceae） [J]. Plant Diversity, 2010, 32(03): 281-284.
[2]	LIAO PengYing, ZHANG YingJun, WANG YiFei, WANG Dong, YANG ChongRen,. Chemical Constituents of Guangdong TuNiuXi (Eupatorium chinense, Compositae) [J]. Plant Diversity, 2010, 32(02): 183-188.
[3]	RAN XinHui, NI Wei, WEI Gang, CHEN ChangXiang, LIU HaiYang. A New Phenolic Glycoside from Chloranthus multistachys(Chloranthaceae) [J]. Plant Diversity, 2010, 32(01): 83-86.
[4]	LI Ming-Ming^, , WANG Kou^, , CHEN Xuan-Qin ^, , PENG Li-Yan , CHENG Xiao , ZHAO Qin-Shi . Two New Glycosides from Diplopterygium laevissimum (Gleicheniaceae) [J]. Plant Diversity, 2009, 31(06): 559-562.
[5]	LI Jun-Ling^,, LUO Xiao-Dong , ZHAO Pei-Ji , ZENG Ying. Post-modification Enzymes Involved in the Biosynthesis of Plant Terpenoids [J]. Plant Diversity, 2009, 31(05): 461-468.
[6]	LI Shi-Fei^, , HUANG Nian-Xu , HAO Xiao-Jiang , LI Ling, LI Shun-Lin. Effect of Chemical Constituents from Syzygium cumini (Myrtaceae) on Glucose Uptake in Insulin-resistant L6 Cells [J]. Plant Diversity, 2009, 31(05): 469-473.
[7]	ZHU Feng ^, , LIU Ling-Li , DI Ying-Tong , HAO Xiao-Jiang, HE Hong-Ping. Scutellin A, a New Neoclerodane Diterpenoid from Scutellaria barbata (Labiatae) [J]. Plant Diversity, 2009, 31(05): 474-476.
[8]	LIU Rong^, , Hsieh Kun-Lung , LIU Ji-Kai. A New Sesquiterpene Lactone from the Leaves of Cynara scolymus (Compositae) [J]. Plant Diversity, 2009, 31(04): 383-385.
[9]	DU Liang-Cheng, TAN Ning-Hua, XU Wen-Yan^, , LOU Li-Li. Plant Cyclopeptides and Possible Biosynthetic Mechanisms [J]. Plant Diversity, 2009, 31(04): 374-382.
[10]	WANG Wei^, , YANG Chong-Ren , ZHANG Ying-Jun. Phenolic Constituents from the Fruits of Amomum tsao-ko ( Zingiberaceae) [J]. Plant Diversity, 2009, 31(03): 284-288.
[11]	WANG Kou^, , LI Ming-Ming^, , CHENG Xiao , XU Gang , PENG Li-Yan, ZHAO Qin-Shi. A New ent-Kaurane Diterpenoid from the Aerial of Dipteris chinensis (Dipteridaceae) [J]. Plant Diversity, 2009, 31(03): 279-283.
[12]	ZHANG Peng-Tao^, , HE Juan, XU Gang, TU Lin , GUO Na , ZHAO Yu, PENG Li-Yan , ZHAO Qin-Shi. A New ent-Kauranoid Diterpenoid from Hicriopteris glauca (Gleicheniaceae) [J]. Plant Diversity, 2009, 31(02): 183-186.
[13]	HUANG Huo-Qiang ^, , TAN Ning-Hua, ZENG Guang-Zhi , JI Chang-Jiu ^, , HAN Hong-Jin, XU Jun-Ju^, , ZHANG Yu-Mei. New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae) [J]. Plant Diversity, 2009, 31(02): 190-192.
[14]	WU Xing-De , HE Juan , XU Gang , PENG Li-Yan, SONG Liu-Dong, ZHAO Qin-Shi. Diphaladine A, a New Lycopodium Alkaloid from Diphasiastrum complanatum (Lycopodiaceae) [J]. Plant Diversity, 2009, 31(1): 93-96.
[15]	LIU Rong , , JIANG Meng-Yuan , , ZHOU Zhong-Yu , , LIU Ji-Kai. Phenolic Glucoside Gallates from the Leaves of Cynara scolymus (Compositae) [J]. Plant Diversity, 2009, 31(1): 89-92.

New Inhibitors of Dual-specificity Protein Phosphatase Cdc25C from Plants

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics